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Multi Online Liposome Extruders System

Description: Genizer Multi Online Liposome Extruders System is high pressure homogenizer or pump online driven, from testing to manufacturing production of liposome and lipopolyplex, for drug and gene delivery; Temperature control is available.
Catalog Number: Multi Online Liposome Extruders System
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  • Catalog No.:
    GOE-8L GOE-20L GOE-8L×2 GOE-8L×4 GOE-8L×6 GOE-8L×8 GOE-20L×2 GOE-20L×4 GOE-20L×6 GOE-20L×8
  • Option: Pressure & Temp. Transmitters:
    GPT-60000psi (Press. Transmitter) GTT-150Mpa (Temp. Transmitter) GTPT-150Mpa (Temp. & Press. Dual) None
  • Warranty:
    Standard 1 Year
  • Compliance:
    None IQ/OQ FDA 21CFR Compliance Explosion-Proof SIP/CIP
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  • Description
Specifications
Description:
 
Genizer Multi Online Liposome Extruders System can be connected with a sanitary pump or high pressure homogenizer and are temperature-controlled, from pilot testing to manufacturing production of pharmaceutical liposomes such as anti-cancer drugs. Homogenous samples can be produced quickly and easily in minutes; typically 3-5 passes are sufficient to produce a sample with uniform liposome size. The Genizer Multi Online Liposome Extruders System is designed to generate homogeneous unilamellar liposomes and lipopolyplex. Extrusion is a one-step procedure that produces liposomes by forcing lipid suspensions of drug, protein or gene through track-etched filters of defined pore size. The Multi Online Extruders System offers minimal dead volume, is easy to clean, suitable for sterilization and compliant with FDA and GMP sanitary standards in pharmaceuticals.
 
Application:
 
Liposome extrusion
 
Performance:
 
Minimal dead volume
The Multi Online Extruders System can control the temperature of the extrusion while producing up to 200L yield of liposome per batch.
 
Specifications
Catalog No. GOE-8L-2 GOE-8L-4 GOE-8L-6 GOE-8L-8 GOE-20L-4
Sample Size 10L-20L 20L-40L 40L-60L 60L-80L 80L-100L
Cooling Jacketed Jacketed Jacketed Jacketed Jacketed
Dimensions 30cm×25cm×25cm 30cm×25cm×25cm 30cm×25cm×25cm 30cm×25cm×25cm 45cm×40cm×30cm
Weight 70kg 120kg 170kg 220kg 400kg
Min. Sample Size 1L 2L 4L 6L 8L
Application Liposome formulation up to production scale
Max. Pressure 1,000 psi-5,000 psi
Temp. Limit 80ºC (176ºF)
Power Type High pressure pump or high pressure homogenizer
Nano-membrane Track-etched membrane
Cleaning Flush to clean/CIP/SIP
Sterilization Whole unit autoclavable
 
Standard Features
Parts 1) Liposome Online Extruder
2) 10 pieces of 100nm membrane (sample pack)
Filter Support Jacketed filter support with pagoda inlet and outlet 
Inlet Type 3/8" high pressure coupling
Outlet Type 3/8" high pressure coupling
Handle Handle for GOE-8L and GOE-20L
Nano Membrane 100nm track-etched polycarbonate membrane
Compatibility Some Parts are compatible with high pressure fittings
Product Material 316L stainless steel, viton
Material Standard Sanitary grade; compliant with FDA and GMP sanitary standards
Warranty 1 year against any manufacturing defects
 
Option Features
Detector 10,000psi sanitary pressure gauge with adaptor, pressure transducer, temperature transducer
Control System Tradition mechanical control: speed, start, stop controls; FDA 21CFR Compliance; Explosion-Proof
Power Sanitary high pressure piston pump/hand pump
Inlet Type Tri-clamp or luer lock
Outlet Type Tri-clamp or luer lock
Nano Membrane 30nm, 50nm, 80nm, 100nm, 200nm, 400nm, 800nm, 1000nm, 2μm, 5μm, 10μm, 20μm, 30μm track-etched membrane (Dia. 142mm, Dia. 293mm)
Multi Extruder Parallel or series connection of multi extruder
URS for Liposome Extruders System.doc
 
Product Introduction and User Guide Video Sharing:
Introduction of Jacketed Liposome Extruder
Introduction of HandExtruder
How to make liposome with HandExtruder